Some viral illnesses may increase a person’s chances of later developing Alzheimer’s disease or another neurodegenerative disorder. Though a causal link cannot be confirmed, an NIH study in which researchers mined the medical records of hundreds of thousands of people in Finland and the United Kingdom found significant associations.

NIH scientists used biobank data to estimate the chances that some viral infections, including influenzas (see picture), may lead to a neurodegenerative disorder diagnosis. Credit NIAID/NIH.

As published in Neuron, the researchers found there may be at least 22 pairings between a neurodegenerative disorder diagnosis and a previous viral infection that led to a hospital visit. The strongest risk association was between viral encephalitis — an inflammation of the brain caused by a virus — and Alzheimer’s disease. Meanwhile, hospitalizations due to pneumonia-causing flu viruses were linked to the diagnoses of several disorders, including dementia, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). The study results also raised the possibility that existing vaccinations may help some people reduce the chances of experiencing these disorders.

Neurodegenerative disorders damage different parts of the nervous system. Typically, this happens later in life and produces a variety of problems, including with thinking, remembering, and moving. Several previous studies have suggested that certain viruses may play a role in each of these disorders. For example, a 1991 study of autopsied brain tissue suggested there may be link between herpes simplex virus and Alzheimer’s disease. More recently, scientists found evidence for a link between the Epstein Barr virus and multiple sclerosis by analyzing patient blood samples and medical records. The latter study sparked the CARD team to conduct this new study.

“After reading the Epstein Barr virus study we realized that for years scientists had been searching, one-by-one, for links between an individual neurodegenerative disorder and a specific virus,” said Michael Nalls, Ph.D., leader of the NIH CARD Advanced Analytics Expert Group and study senior author.

Led by Kristin S. Levine, M.S. and Hampton L. Leonard, M.S., two NIH CARD data scientists, the researchers mined the medical records of 300,000 individuals stored in FinnGen, a nationwide Finnish biobank. Specifically, they searched for individuals who had one of six neurodegenerative disorder diagnoses: Alzheimer’s disease, ALS, generalized dementia, multiple sclerosis, Parkinson’s disease, or vascular dementia; and then checked to see if a viral infection caused those individuals to make a prior visit to the hospital. Hospitalizations due to COVID-19 were not included in the study.

Initially, they found 45 significant associations between a neurodegenerative disease diagnosis and a previous viral infection. That number narrowed to 22 associations after the scientists performed a second search of UKBiobank, which contains the records of 500,000 individuals from the United Kingdom.

Of all the neurodegenerative disorders, generalized dementia had the most associations, with links to six different virus exposures. These exposures were categorized as viral encephalitis, viral warts, other viral diseases, all influenza, influenza and pneumonia, and viral pneumonia. Individuals who had viral encephalitis were at least 20 times more likely to be diagnosed with Alzheimer’s than those who did not experience that virus.

Severe cases of influenza were linked to the widest range of risks. Influenza and pneumonia exposures were associated with all the neurodegenerative disorder diagnoses except multiple sclerosis.

This study was funded by the Intramural Research Program at NIA (ZIAAG000535).

by Patricia Schallert

I met Robert Warnagieris, Ed.D at the Ventura Retired Men’s Group. This is what he has to say about his life as a retired senior.

“I was born in Chicago but came to California at the age of 6 months.  Therefore, I am a California product who grew up on the West Coast and received early schooling in San Luis Obispo County.  I ended up in Ventura in 1970 because I like what the VC county seat of Ventura had to offer in terms of cultural, educational, youth/senior programs, medical facilities, shopping and climate opportunities for me and my family. I had put in 38 ½ years in with the US Navy as a civilian and was able to retire with 40 years of credit.  It was time for me to move on. I am happy being retired from full time employment, but I really didn’t retire from an active life, I just don’t get paid.  I have been retired for 28 years.”

“I have more time to pursue time with my wife, hobbies, home maintenance/landscaping and community activities. I don’t have to meet any special schedule nor travel for business purposes.  I am free to stay home and scratch the dog’s ears if I please. I can do most anything I desire, and I do.  I am a versatile person and often say I have expertise in many fields but master of none.  I have been able to use all my experience, knowledge, and skills in many different venues.”

“When I retired, I expected to be able to switch from government service to an educational teaching or leadership position easily.  It was not so easy; however, I was able to continue my graduate level teaching on a part-time basis.”

“There were unexpected changes in my marital status and the eventual stability I achieved in that regard. As an 88-year-old retired person I spend time taking care of my wife and myself, pursuing physical fitness, hunting, fishing, golfing, community activities, various forms of entertainment, gardening/landscaping, watercolor painting, writing, time with my family, visiting friends, reading, walking the dog daily, cooking, maintaining my home, financial activities, and, of course, visits with multiple doctors.  Since the pandemic and aging, my long-distance traveling has been limited.  I tend to be an extreme do-it-yourselfer.”

“My parents encouraged me to graduate from high school in 3 years and then enroll for college.  I graduated at the age of 17 and enrolled in an engineering major at Cal Poly (SLO).  The continued pursuance of education to advance in many fields has been a major factor in my life.”

“In my 20’s I didn’t realize what I could achieve with perseverance.  I’m no genius but I set goals and achieved them. I wrote an Ethical Will for my family and listed 48 values that guide my life, ranging from education to having a dog.  They are in no particular order, however, high on the list are family matters, education, physical fitness, citizenship, career, professionalism, integrity, long term friends, and spiritual matters.”

Editor: If you are a senior (over 70-years please), or know of one, who would like to share their retirement, or job, with us please let us know at [email protected].