NIH launches international study of AMD progression

A new clinical study led by the National Eye Institute (NEI), part of the National Institutes of Health, will follow 500 people over five years to learn more about the natural history of early age-related macular degeneration (AMD). By using the latest technologies to visualize structures within the eye and measure their function, researchers hope to identify biomarkers of disease progression, well before it advances to late-stage disease and causes vision loss. AMD is the leading cause of vision impairment and blindness among people age 50 and older in the United States.

People with early AMD typically do not have daylight vision loss. As it progresses, AMD causes cells to die in the retina, the light-sensitive tissue at the back of the eye. Much of the damage occurs in the macula, an area of the retina responsible for sharp, central vision.

Only about 10 to 20 percent of people with early AMD progress to late-stage disease within five years. It is difficult to predict who will progress because AMD is a complex, multifactorial disease influenced by a combination of age, family history, genetic and health behavioral factors. A diet rich in green leafy vegetables and fish, for example, may reduce the risk, while smoking cigarettes increases it.

The AMD Ryan Initiative Study (ARIS) will track the eye health of 200 people who have bilateral early AMD, defined by the presence of medium-size drusen, yellowish deposits that accumulate under the retina. In addition, ARIS will include 200 people with early, reticular pseudodrusen, a type of lesion that causes the retina to have a giraffe-like macular pattern.

All participants will undergo routine spectral domain optical coherence tomography (SD-OCT), a type of imaging that shows high-resolution, cross-sectional views of the retina. SD-OCT is sensitive enough to detect even small changes in the volume of drusen over time.

Researchers at each of the 20 ARIS study sites will track drusen volume changes as well as other findings on SD-OCT to see if they correspond to functional changes in visual acuity and dark adaptation.

Ideally, the investigators would like to complement their studies by analyzing the participants’ DNA to look for correlations between genes and AMD progression. In total, scientists have so far identified 52 independent genetic variants associated with AMD. Further research is needed to determine if and how these variants influence the development and progression of the disease.

The study is named after the late Stephen J. Ryan, M.D., a widely recognized expert in retinal disease and president of the Doheny Eye Institute, an independent non-profit institution supporting ophthalmic research, training and clinical care. The Stephen J. Ryan Initiative for Macular Research is an interdisciplinary program at the Doheny Eye Institute that supports the ARIS investigation.

For more information or to enroll in ARIS, visit and search for NCT03092492.

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